It’s all about understanding your biology and the crucial role of two powerful hormones — leptin and adiponectin.

Leptin is a signaling hormone that helps regulate appetite by telling your brain to either “keep eating and store fat” or “stop eating and burn fat.” Too much leptin signals the brain to “keep eating and store fat.” At this point, your brain ignores all other weight loss messages.

Adiponectin is a hormone known for regulating glucose levels and insulin sensitivity. Lower-than-normal adiponectin levels are associated with excess fat.